HMGA1 and HMGA2 expression and comparative analyses of HMGA2, Lin28and let-7 miRNAs in oral squamous cell carcinoma
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منابع مشابه
Author's response to reviews Title:HMGA1 and HMGA2 expression and comparative analyses of HMGA2, Lin28 and let-7 miRNAs in oral squamous cell carcinoma Authors:
Katharina A. Sterenczak ([email protected]) Andre Eckardt ([email protected]) Andreas Kampmann ([email protected]) Saskia Willenbrock ([email protected]) Nina Eberle ([email protected]) Florian Länger ([email protected]) Sven Kleinschmidt ([email protected]) Marion Hewicker-Trautwein...
متن کاملExpressions of miR-30c and let-7a are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva
Malignant tumors of the vulva, most of them squamous cell carcinomas, account for only 5% of cancers of the female genital tract. Though little is known about the genetic features of these tumors, the Fragile Histidine Triad (FHIT) and High Mobility Group AT-hook 2 (HMGA2) genes were found deregulated. We wanted to gain more knowledge about the expression of HMGA2-related miRNAs such as miR-30c...
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Overexpression of HMGA2 is common in uterine leiomyomas (ULM). The expression of HMGA2 in its malignant counterpart - uterine leiomyosarcomas (ULMS) remains undetermined. Recently it has been shown that repression of HMGA2 by microRNA let-7s is a critical molecular regulatory mechanism associated with tumour growth in many tumours and cell types, including leiomyomas. To test whether HMGA2 and ...
متن کاملLet-7c inhibits migration and epithelial–mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2
To elucidate the molecular mechanisms underlying the progression of head and neck squamous cell carcinoma (HNSCC), we investigated the function of let-7c as a tumor suppressor. Let-7c expression was significantly down-regulated in HNSCC tumor tissues and cell lines. In vitro and in vivo studies revealed that let-7c negatively regulated HNSCC proliferation, migration and epithelial-mesenchymal t...
متن کاملThe tumor suppressor microRNA let-7 represses the HMGA2 oncogene.
HMGA2, a high-mobility group protein, is oncogenic in a variety of tumors, including benign mesenchymal tumors and lung cancers. Knockdown of Dicer in HeLa cells revealed that the HMGA2 gene is transcriptionally active, but its mRNA is destabilized in the cytoplasm through the microRNA (miRNA) pathway. HMGA2 was derepressed upon inhibition of let-7 in cells with high levels of the miRNA. Ectopi...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2014
ISSN: 1471-2407
DOI: 10.1186/1471-2407-14-694